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Breast Cancer

Breast Cancer Treatment Options

Because there are several types of breast cancer, there are also several types of breast cancer treatment. At Cancer Care Centers of Brevard, our dedicated team of medical oncologists use the latest breast cancer treatment technologies to create a unique treatment plan for each patient. They are available to take questions and guide you through the process starting a cancer treatment plan that is right for you.

The following is a broad description of breast cancer treatments that may be used as part of your treatment plan.

Breast Cancer Surgery

Most women will receive surgery as part of their breast cancer treatment. Your oncologist and breast surgeon will discuss your options to compare the benefits and risks of each, and describe how each will change the way you look:

  • Breast-sparing surgery: Also called breast-conserving surgery, this operation removes the cancer rather than the breast. It can be done as a lumpectomy or segmental mastectomy (also called a partial mastectomy). Sometimes an excisional biopsy is the only surgery a woman needs because the surgeon was able to remove the whole lump.
  • Mastectomy: This operation removes the entire breast (or as much of the breast tissue as possible) and possibly some of the lymph nodes. This is called a total mastectomy. Another option is a modified radical mastectomy, where the entire breast and most or all of the lymph nodes are removed. In some cases, a skin-sparing mastectomy may be an option. For this approach, your surgeon removes as little skin as possible.

The surgeon usually does a Sentinel Lymph node biopsy at this time to see if there may be lymph node involvement.

You may choose to have breast reconstruction, which involves using plastic surgery to rebuild the shape of the breast. It may be done at the same time as the cancer surgery or later. If you’re considering breast reconstruction, you may wish to talk with a plastic surgeon before having cancer surgery.

Radiation Therapy for Breast Cancer

To destroy breast cancer cells that remain in the area after surgery, radiation therapy may be recommended. It could also be given to the nearby lymph nodes. For women who had a modified radical mastectomy, it may or may not be recommended depending on the size of the tumor, whether it has spread to lymph nodes and how many lymph nodes.

There are two types of radiation therapy that oncologists use to treat breast cancer. Depending on your situation, you may receive both types, which include:

  • External radiation therapy, which comes from a large machine outside the body. Treatments will be given at a hospital or clinic for treatment and last five days a week for four to six weeks. External radiation is the most common type used for breast cancer.
  • Internal radiation therapy (commonly called brachytherapy), where the oncologist places one or more thin tubes inside the breast through a tiny incision. Most commonly, radioactive pellets are loaded into the tubes each day for about 5 days and pointed at the area where there was cancer. At the end of the treatment the device with the tubes is removed. This is a rapidly advancing breast cancer treatment technology and your radiation oncologist can discuss whether this type of treatment is best for you.

Hormone Therapy to Treat Breast Cancer

If lab tests show that the tumor in your breast has hormone receptors, then hormone therapy may be an option. Hormone therapy, also sometimes called anti-hormone treatment, keeps cancer cells from getting or using the natural hormones (estrogen and progesterone) they need to grow.

Hormone therapy is usually given along with other therapies (adjuvant) and may be recommended for several years after your other breast cancer treatments are complete.

Hormone therapy options before menopause

If you have not gone through menopause, the options include:

  • Tamoxifen: This drug can prevent the original breast cancer from returning and also helps prevent the development of new cancers in the other breast. As treatment for metastatic breast cancer, tamoxifen slows or stops the growth of cancer cells that are in the body. Tamoxifen comes in pill form and is taken every day for five years. Generally, the side effects of tamoxifen are similar to some of the symptoms of menopause with the most common being hot flashes and vaginal discharge. Others are irregular menstrual periods, thinning bones, headaches, fatigue, nausea, vomiting, vaginal dryness or itching, irritation of the skin around the vagina, and skin rash. Serious side effects are rare, but they include blood clots, strokes, uterine cancer, and cataracts. You may want to read the NCI fact sheet Tamoxifen.
  • LH-RH agonist: This type of drug can prevent the ovaries from making estrogen, which causes the estrogen level to fall slowly.This type of drug may be given by injection under the skin in the stomach area. Side effects include hot flashes, headaches, weight gain, thinning bones, and bone pain. Leuprolide and goserelin are examples of LH-RH agonists.
  • Surgery to remove your ovaries: Your ovaries are your body’s main source of estrogen until you go through menopause. When the surgeon removes your ovaries, this source of estrogen is also removed. (A woman who has gone through menopause wouldn’t benefit from this kind of surgery because her ovaries produce much less estrogen.) When the ovaries are removed, menopause occurs right away. The side effects are often more severe than those caused by natural menopause. Your healthcare team can suggest ways to cope with these side effects.

Breast Cancer Chemotherapy

Chemotherapy drugs kill cancer. They are usually given through a vein (intravenous) or as a pill. If chemotherapy is part of your treatment plan, you will probably receive a combination of drugs based on the type, stage and grade of breast cancer you have.

Some anticancer drugs cause damage to the ovaries. If you have not gone through menopause yet, you may experience symptoms such as hot flashes and vaginal dryness. Your menstrual periods may no longer be regular or may stop. You may become infertile (unable to become pregnant). For women over the age of 35, this damage to the ovaries is likely to be permanent.

On the other hand, you may remain able to become pregnant during chemotherapy. Before treatment begins, you should talk with your doctor about birth control because many drugs given during the first trimester are known to cause birth defects.

Hormone Therapy

If your breast cancer was hormone receptor positive you may be a candidate for hormone therapy drugs that will help your body from producing too much of the hormone that fueled the breast cancer. These are taken every day for 5-10 years after diagnosis.

Common hormone therapies for breast cancer include:

  • Tamoxifen: Premenopausal and post-menopausal women are able to receive tamoxifen for 2-5 years after a breast cancer diagnosis. If tamoxifen is given for less than five years, then an aromatase inhibitor often is given to supplement the remaining years for postmenopausal women. Hot flashes, night sweats, and vaginal dryness are common side effects as well as an increased risk of blood clots and stroke.
  • Aromatase inhibitors: This type of drug prevents the body from making a form of estrogen (estradiol). This hormone therapy is for post menopausal women. Common side effects include hot flashes, nausea, vomiting, and painful bones or joints. Serious side effects include thinning bones and an increase in cholesterol. Anastrozole, exemestane, and letrozole are examples of aromatase inhibitors.

Targeted Therapy

Another breast cancer treatment approach is targeted therapy. Targeted therapy uses drugs that block the growth of breast cancer cells. For example, targeted therapy may block the action of the HER2 protein that stimulates the growth of breast cancer cells.

Trastuzumab (Herceptin®), lapatinib (TYKERB®), or other approved targeted therapies for breast cancer may be given to a woman whose lab tests show that her breast tumor has too much HER2.